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The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. . while in about 30% authors from laboratories based in at least two countries . Clinical Trials Based on Human Pluripotent Stem Cells.
Table of contents
- Follow journal
- Quality control guidelines for clinical-grade human induced pluripotent stem cell lines.
- Stem Cells for Cystic Fibrosis Therapy
- Twenty years on, measuring the impact of human stem cells
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Faculty Development. Community Engagement. Research Areas. Research Labs. Clinical Trials. Research Cores. Research Administration. Graduate Medical Education.
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Continuing Medical Education. Graduate School of Biomedical Sciences. Understanding the mechanics of embryonic stem cells may well be the key to the most dramatic breakthroughs in regeneration medicine. This research includes the use of NT nuclear transfer technology and iPS induced pluripotent stem cell technology to create new stem cell lines, which serve as models for studying and treating disorders such as cancer, diabetes, cardiovascular disease, autoimmune disease, and neurodegenerative disorders such as Alzheimer's, Parkinson's, and Lou Gehrig's diseases.
The institute continues to be the global epicenter of the hunt for cancer stem cells. Nat Med. Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery. J Am Acad Orthop Surg. Drukker M, Benvenisty N. The immunogenicity of human embryonic stem-derived cells.
Quality control guidelines for clinical-grade human induced pluripotent stem cell lines.
Trends Biotechnol. Duncan ID. Oligodendrocytes and stem cell transplantation: their potential in the treatment of leukoencephalopathies. J Inherit Metab Dis. Modeling the pro-inflammatory tumor microenvironment in acute lymphoblastic leukemia predicts a breakdown of hematopoietic-mesenchymal communication networks.
Front Physiol. Hematopoietic support capacity of mesenchymal stem cells: biology and clinical potential. Arch Med Res. Fehlings MG, Vawda R. Cellular treatments for spinal cord injury: the time is right for clinical trials. Concise review: ex vivo expansion of cord blood-derived hematopoietic stem and progenitor cells: basic principles, experimental approaches, and impact in regenerative medicine. Stem Cells Transl Med.
Embryonic stem cells and cell replacement therapies in the nervous system.
Med Sci Paris ; 19 — J Clin Med. Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages. Expert Opin Ther Targets. A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem iPS cells.
PLoS One. Adv Exp Med Biol. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Disease modeling using 3D organoids derived from human induced pluripotent stem cells. Int J Mol Sci. Comparison of human mesenchymal stem cells derived from bone marrow, synovial fluid, adult dental pulp, and exfoliated deciduous tooth pulp.
Int J Oral Maxillofac Surg. Kfoury Y, Scadden DT. Mesenchymal cell contributions to the stem cell niche. Nanotopography promotes pancreatic differentiation of human embryonic stem cells and induced pluripotent stem cells.
Stem Cells for Cystic Fibrosis Therapy
ACS Nano. Hydrogels with an embossed surface: an all-in-one platform for mass production and culture of human adipose-derived stem cell spheroids. Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest. Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity. Long-term maintenance of human induced pluripotent stem cells by automated cell culture system.
Sci Rep. Cerebral organoids model human brain development and microcephaly.
Neural stem cells in the subventricular zone are a source of astrocytes and oligodendrocytes, but not microglia. Dev Neurosci.
Twenty years on, measuring the impact of human stem cells
Chemical approaches to stem cell biology and therapeutics. Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. Chemical modulation of cell fate in stem cell therapeutics and regenerative medicine. Cell Chem Biol. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
Marx V. Stem cells: disease models that show and tell. Nat Methods. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Melton D. In: Lanza R, Atala A, editors.
Essentials of Stem Cell Biology. London: Elsevier; Comparison of pure and mixed populations of human fetal-derived neural progenitors transplanted into intact adult rat brain. Exp Neurol. In vitro evidence of the presence of mesenchymal stromal cells in cervical cancer and their role in protecting cancer cells from cytotoxic T cell activity.
Stem Cells Dev. Engineering personalized neural tissue by combining induced pluripotent stem cells with fibrin scaffolds. Biomater Sci. Nakamura M, Okano H. Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells. Cell Res. Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors.